Project description:Immune checkpoint inhibitors combined with chemotherapy represent a promising treatment option in triple-negative breast cancer (TNBC). However, response rates are still relatively low necessitating the design of novel therapeutic strategies to improve clinical outcomes. Here, we describe a triple combination of anti-PDL-1 immune checkpoint blockade, epigenetic modulation thorough BET bromodomain inhibition, and chemotherapy with paclitaxel that effectively inhibits both primary and metastatic tumor growth in two different syngeneic murine breast cancer models. Detailed cellular and molecular profiling of tumors from single and combination treatment arms revealed increased T and B cell infiltration and macrophage reprogramming from M1 to a M2 phenotype in mice treated with triple combination.

2023-08-15 | GSE229422 | GEO

Combination therapies to improve the efficacy of immunotherapy in triple-negative breast cancer [ATAC-seq]

2023-08-15 | GSE229426 | GEO

Checkpoint inhibition in advanced gastroesophageal cancer: clinical trial data, molecular subtyping, predictive biomarkers, and the potential of combination therapies.

Project description: Not available

| S-EPMC6737389 | biostudies-literature

Transcriptomic signatures of Auger electron radioimmunotherapy using nuclear targeting 111In-trastuzumab for potential combination therapies

Project description:The aim of this study was to identify targetable molecular signatures for enhancing the cytotoxic effects of In-111-trastuzumab-NLS using microarray technology. Changes in gene expression in SKBR3 cells untreated or treated with unlabeled or In-111-labeled antibodies for 7 days were measured. Three independent experiments in each condition were performed.

2015-09-01 | E-GEOD-67193 | biostudies-arrayexpress

Gemcitabine combination therapies induce apoptosis in uterine carcinosarcoma patient-derived organoids

Project description: Not available

| S-EPMC10966467 | biostudies-literature

Combination Therapies to Improve the Efficacy of Immunotherapy in Triple-negative Breast Cancer.

Project description: Not available

| S-EPMC10618734 | biostudies-literature