Potential Clinical Value of Biomarker-Guided Emergency Triage for Thoracic Aortic Dissection.

ABSTRACT: Aim: Thoracic aortic dissection (TAD) is a high-risk vascular disease. The mortality rate of untreated TADs in 24 h was as high as 50%. Thus, rapid diagnosis of TAD in the emergency department would get patients to the right treatments to save their lives. Methods: We profiled the proteome of aortic tissues from TAD patients using a label-free quantification proteomics method. The differentially expressed proteins were screened and subjected to bioinformatics analysis. Candidate biomarkers were selected and validated in independent serum samples using enzyme-linked immunosorbent assays (ELISAs). The diagnostic values were further predicted via receiver operating characteristic (ROC) curve analysis. Results: A total of 1,141 differentially expressed proteins were

SUBMITTER: Qiu P 

PROVIDER: S-EPMC8790093 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature