Type 2 Inflammation in Eosinophilic Esophagitis: From Pathophysiology to Therapeutic Targets.

ABSTRACT: Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease of the esophagus characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation, whose incidence is rising. It significantly affects patients' quality of life and, if left untreated, results in fibrotic complications. Although broad consensus has been achieved on first-line therapy, a subset of patients remains non-responder to standard therapy. The pathogenesis of EoE is multifactorial and results from the complex, still mostly undefined, interaction between genetics and intrinsic factors, environment, and antigenic stimuli. A deep understanding of the pathophysiology of this disease is pivotal for the development of new therapies. This review provides a co

SUBMITTER: Racca F 

PROVIDER: S-EPMC8790151 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature