Unknown

Dataset Information

0

African Swine Fever Virus MGF360-14L Negatively Regulates Type I Interferon Signaling by Targeting IRF3.


ABSTRACT: African swine fever (ASF) is a devastating infectious disease caused by African swine fever virus (ASFV). The ASFV genome encodes multiple structural and non-structural proteins that contribute to evasion of host immunity. In this study, we determined that the viral non-structural protein MGF360-14L inhibits interferon-β (IFN-β) promoter activity induced by cGAS-STING signaling. MGF360-14L was also found to downregulate expression of the IRF3 protein and promote its degradation through ubiquitin-meditated proteolysis. Moreover, MGF360-14L was shown to interact with and destabilize IRF3 by facilitating E3 ligase TRIM21-mediated K63-linked ubiquitination of IRF3. Overall, our study revealed that MGF360-14L promotes degradation of IRF3 through TRIM21, thereby inhibiting type I interferon production. These findings provide new insights into the mechanisms underlying ASFV immune evasion.

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8790226 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC8785597 | biostudies-literature
| S-EPMC7606853 | biostudies-literature
| S-EPMC10889005 | biostudies-literature
| S-EPMC8387055 | biostudies-literature
2022-02-17 | PXD027260 | Pride
| S-EPMC8788333 | biostudies-literature
| S-EPMC8989734 | biostudies-literature
| S-EPMC5476288 | biostudies-other
| S-EPMC8473002 | biostudies-literature
| S-EPMC10688321 | biostudies-literature