Involvement of the long intergenic non-coding RNA LINC00461 in schizophrenia.

ABSTRACT:

Objective

LINC00461 is a highly conserved intergenic non-protein coding RNA that was implicated in schizophrenia at the genome-wide level. We aim to explore potential mechanisms underlying the involvement of LINC00461 in schizophrenia.

Methods

We performed a meta-analysis to investigate the association of LINC00461 rs410216 with schizophrenia, and evaluate the effects of the rs410216 on hippocampal volume and function using the functional magnetic resonance imaging (fMRI) analysis. We utilized the GTEx dataset to profile the expression distribution of LINC00461 across different brain regions, and to investigate the potential impact of the risk SNPs on the expression of LINC00461 and other nearby genes. We compared blood expression levels of LINC00461 between schizophrenia pa

SUBMITTER: Rao S 

PROVIDER: S-EPMC8790831 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature