Dynamics and Pathways of Chromosome Structural Organizations during Cell Transdifferentiation.

ABSTRACT: Direct conversion of one differentiated cell type into another is defined as cell transdifferentiation. In avoidance of forming pluripotency, cell transdifferentiation can reduce the potential risk of tumorigenicity, thus offering significant advantages over cell reprogramming in clinical applications. Until now, the mechanism of cell transdifferentiation is still largely unknown. It has been well recognized that cell transdifferentiation is determined by the underlying gene expression regulation, which relies on the accurate adaptation of the chromosome structure. To dissect the transdifferentiation at the molecular level, we develop a nonequilibrium landscape-switching model to investigate the chromosome structural dynamics during the state transitions between the human fibroblast and ne

SUBMITTER: Chu X 

PROVIDER: S-EPMC8791059 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature