Cholesterol mediates membrane curvature during fusion events.
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ABSTRACT:
SUBMITTER: Ivankin A
PROVIDER: S-EPMC8792958 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Publications
Cholesterol mediates membrane curvature during fusion events.
Ivankin Andrey A Kuzmenko Ivan I Gidalevitz David D
Physical review letters 20120605 23
Biomembranes undergo extensive shape changes as they perform vital cellular functions. The mechanisms by which lipids and proteins control membrane curvature remain unclear. We use x-ray reflectivity, grazing incidence x-ray diffraction, and epifluorescence microscopy to study binding of HIV-1 glycoprotein gp41's membrane-bending domain to DPPC/cholesterol monolayers of various compositions at the air-liquid interface. The results offer a new insight into how membrane curvature could be regulate ...[more]
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