Global Characterization of Metabolic Genes Regulating Survival and Immune Infiltration in Osteosarcoma.

ABSTRACT: Background: The alterations in metabolic profile of tumors have been identified as one of the prognostic hallmarks of cancers, including osteosarcoma. These alterations are majorly controlled by groups of metabolically active genes. However, the regulation of metabolic gene signatures in tumor microenvironment of osteosarcoma has not been well explained. Objectives: Thus, we investigated the sets of previously published metabolic genes in osteosarcoma patients and normal samples. Methods: We applied computational techniques to identify metabolic genes involved in the immune function of tumor microenvironment (TME) and survival and prognosis of the osteosarcoma patients. Potential candidate gene PAICS (phosphoribosyl aminoimidazole carboxylase, phosphoribosyl

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC8793845 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature