Spontaneous transient states of fronto-temporal and default-mode networks altered by suicide attempt in major depressive disorder.

ABSTRACT: Major depressive disorder (MDD) is associated with increased suicidality, and it's still challenging to identify suicide in clinical practice. Although suicide attempt (SA) is the most relevant precursor with multiple functional abnormalities reported from neuroimaging studies, little is known about how the spontaneous transient activated patterns organize and coordinate brain networks underlying SA. Thus, we obtained resting-state magnetoencephalography data for two MDD subgroups of 44 non-suicide patients and 34 suicide-attempted patients, together with 49 matched health-controls. For the source-space signals, Hidden Markov Model (HMM) helped to capture the sub-second dynamic activity via a hidden sequence of finite number of states. Temporal parameters and spectral activation were acqui

SUBMITTER: Zhang S 

PROVIDER: S-EPMC8794625 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature