Synthesis and in vitro assay of hydroxyxanthones as antioxidant and anticancer agents.

ABSTRACT: In the present work, three hydroxyxanthones were synthesized in 11.15-33.42% yield from 2,6-dihydroxybenzoic acid as the starting material. The chemical structures of prepared hydroxyxanthones have been elucidated by using spectroscopic techniques. Afterward, the hydroxyxanthones were evaluated as antioxidant agents through radical scavenging assay; and anticancer agents through in vitro assays against WiDr, MCF-7, and HeLa cancer cell lines. Hydroxyxanthone 3b was categorized as a strong antioxidant agent (IC₅₀ = 349 ± 68 µM), while the other compounds were categorized as moderate antioxidant agents (IC₅₀ > 500 µM). On the other hand, hydroxyxanthone 3a exhibited the highest anticancer activity (IC₅₀ = 184 ± 15 µM) and the highest selectivity (SI = 18.42)

SUBMITTER: Fatmasari N 

PROVIDER: S-EPMC8795354 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature