Genetic diversity estimates for the Caenorhabditis Intervention Testing Program screening panel.

ABSTRACT: The Caenorhabditis Intervention Testing Program (CITP) was founded on the principle that compounds with positive effects across a genetically diverse test-set should have an increased probability of engaging conserved biochemical pathways with mammalian translational potential. To fulfill its mandate, the CITP uses a genetic diversity panel of Caenorhabditis strains for assaying longevity effects of candidate compounds. The panel comprises 22 strains from three different species, collected globally, to achieve inter-population genetic diversity. The three represented species, C. elegans, C. briggsae, and C. tropicalis, are all sequential hermaphrodites, which simplifies experimental procedures while maximizing intra-population homogeneity. Here, we presen

SUBMITTER: Teterina AA 

PROVIDER: S-EPMC8796004 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature