Corticosteroids as risk factor for COVID-19-associated pulmonary aspergillosis in intensive care patients.

ABSTRACT:

Purpose

Corticosteroids, in particular dexamethasone, are one of the primary treatment options for critically ill COVID-19 patients. However, there are a growing number of cases that involve COVID-19-associated pulmonary aspergillosis (CAPA), and it is unclear whether dexamethasone represents a risk factor for CAPA. Our aim was to investigate a possible association of the recommended dexamethasone therapy with a risk of CAPA.

Methods

We performed a study based on a cohort of COVID-19 patients treated in 2020 in our 13 intensive care units at Charité Universitätsmedizin Berlin. We used ECMM/ISHM criteria for the CAPA diagnosis and performed univariate and multivariable analyses of clinical parameters to identify risk factors that could result in a diagnosis of CAPA.

Result

SUBMITTER: Leistner R 

PROVIDER: S-EPMC8796178 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature