Comprehensive analysis of the NME gene family functions in breast cancer.

ABSTRACT:

Background

An increasing amount of research over recent years on the anti-metastasis function of the non-metastatic (NME) gene family has been challenged, with some studies identifying its involvement in the promotion of oncogenesis. Therefore, the specific functions of the NME gene family require redefining through a comprehensive analysis of tumor heterogeneity and survival benefit. However, the functions of NME genes have not been comprehensively investigated in breast cancer (BC).

Methods

In this study, ONCOMINE, GEPIA, Kaplan-Meier plotter, cBioPortal, String, and metascape databases were utilized for comparison of the mRNA expression, patient survival and network analysis of NME-associated signaling pathways in BC patients.

Results

The mRNA

SUBMITTER: Wu H 

PROVIDER: S-EPMC8798044 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature