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The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2.

ABSTRACT: In the mouse, Period-2 (Per2) expression in tissues peripheral to the suprachiasmatic nuclei (SCN) increases during sleep deprivation and at times of the day when animals are predominantly awake spontaneously, suggesting that the circadian sleep-wake distribution directly contributes to the daily rhythms in Per2. We found support for this hypothesis by recording sleep-wake state alongside PER2 bioluminescence in freely behaving mice, demonstrating that PER2 bioluminescence increases during spontaneous waking and decreases during sleep. The temporary reinstatement of PER2-bioluminescence rhythmicity in behaviorally arrhythmic SCN-lesioned mice submitted to daily recurring sleep deprivations substantiates our hypothesis. Mathematical modeling revealed that PER2 dynamics can be described by a damped harmonic oscillator driven by two forces: a sleep-wake-dependent force and an SCN-independent circadian force. Our work underscores the notion that in peripheral tissues the clock gene circuitry integrates sleep-wake information and could thereby contribute to behavioral adaptability to respond to homeostatic requirements.

SUBMITTER: Hoekstra MM

PROVIDER: S-EPMC8798053 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2.

Hoekstra Marieke Mb MM Jan Maxime M Katsioudi Georgia G Emmenegger Yann Y Franken Paul P

eLife 20211213

In the mouse, Period-2 (Per2) expression in tissues peripheral to the suprachiasmatic nuclei (SCN) increases during sleep deprivation and at times of the day when animals are predominantly awake spontaneously, suggesting that the circadian sleep-wake distribution directly contributes to the daily rhythms in Per2. We found support for this hypothesis by recording sleep-wake state alongside PER2 bioluminescence in freely behaving mice, demonstrating that PER2 bioluminescence i ...[more]

PMID: 34895464

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The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2.

Publications

The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2.

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