Identifying the potential regulators of neutrophils recruitment in hepatocellular carcinoma using bioinformatics method.

ABSTRACT:

Background

Neutrophils play a crucial role in the development and progression of hepatocellular carcinoma (HCC); however, the mechanism underlying neutrophil recruitment is not fully understood. Therefore, we aimed to explore the potential genes or pathways related to neutrophil recruitment in the cancer microenvironment.

Methods

We downloaded TCGA HCC gene expression profiles, the abundance of 22 different immune cells in HCC patients, and patient survival information. We used Kaplan-Meier survival analysis to determine if neutrophils were related to survival. Next, we screened different expression genes (DEGs) between patients with high and low level of neutrophils. We then identified the transcription factor and its targets in the fence of DEGs. Then, we carried out enric

SUBMITTER: Luan M 

PROVIDER: S-EPMC8798716 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature