Metals and Breast Cancer Risk: A Prospective Study Using Toenail Biomarkers.

ABSTRACT: The role of metals in breast cancer is of interest because of their carcinogenic and endocrine-disrupting capabilities. Evidence from epidemiologic studies remains elusive, and prior studies have not investigated metal mixtures. In a case cohort nested within the Sister Study (enrolled in 2003-2009; followed through September 2017), we measured concentrations of 15 metals in toenails collected at enrollment in a race/ethnicity-stratified sample of 1,495 cases and a subcohort of 1,605 women. We estimated hazard ratios and 95% confidence intervals for each metal using Cox regression and robust variance. We used quantile g-computation to estimate the joint association between multiple metals and breast cancer risk. The average duration of follow-up was 7.5 years. There was little evidence sup

SUBMITTER: Niehoff NM 

PROVIDER: S-EPMC8799900 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature