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A Bayesian finite-element trained machine learning approach for predicting post-burn contraction

ABSTRACT: Burn injuries can decrease the quality of life of a patient tremendously, because of esthetic reasons and because of contractions that result from them. In severe case, skin contraction takes place at such a large extent that joint mobility of a patient is significantly inhibited. In these cases, one refers to a contracture. In order to predict the evolution of post-wounding skin, several mathematical model frameworks have been set up. These frameworks are based on complicated systems of partial differential equations that need finite element-like discretizations for the approximation of the solution. Since these computational frameworks can be expensive in terms of computation time and resources, we study the applicability of neural networks to reproduce the finite element results. Our neural network is able to simulate the evolution of skin in terms of contraction for over one year. The simulations are based on 25 input parameters that are characteristic for the patient and the injury. One of such input parameters is the stiffness of the skin. The neural network results have yielded an average goodness of fit (

Supplementary Information

The online version contains supplementary material available at 10.1007/s00521-021-06772-3.

SUBMITTER: Egberts G

PROVIDER: S-EPMC8801043 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Concussion is a significant public health problem affecting 1.6-2.4 million Americans annually. An alternative to reducing the burden of concussion is to reduce its incidence with improved protective equipment and injury mitigation systems. Finite element (FE) models of the brain response to blunt trauma are often used to estimate injury potential and can lead to improved helmet designs. However, these models have yet to incorporate how the patterns of brain connectivity disruption after impact affects the relay of information in the injured brain. Furthermore, FE brain models typically do not consider the differences in individual brain structural connectivities and their purported role in concussion risk. Here, we use graph theory techniques to integrate brain deformations predicted from FE modeling with measurements of network efficiency to identify brain regions whose connectivity characteristics may influence concussion risk. We computed maximum principal strain in 129 brain regions using head kinematics measured from 53 professional football impact reconstructions that included concussive and non-concussive cases. In parallel, using diffusion spectrum imaging data from 30 healthy subjects, we simulated structural lesioning of each of the same 129 brain regions. We simulated lesioning by removing each region one at a time along with all its connections. In turn, we computed the resultant change in global efficiency to identify regions important for network communication. We found that brain regions that deformed the most during an impact did not overlap with regions most important for network communication (Pearson's correlation, ? = 0.07; p = 0.45). Despite this dissimilarity, we found that predicting concussion incidence was equally accurate when considering either areas of high strain or of high importance to global efficiency. Interestingly, accuracy for concussion prediction varied considerably across the 30 healthy connectomes. These results suggest that individual network structure is an important confounding variable in concussion prediction and that further investigation of its role may improve concussion prediction and lead to the development of more effective protective equipment.

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A Bayesian finite-element trained machine learning approach for predicting post-burn contraction

Supplementary Information

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