Dataset Information

Filtering respiratory motion artifact from resting state fMRI data in infant and toddler populations.

ABSTRACT: The importance of motion correction when processing resting state functional magnetic resonance imaging (rs-fMRI) data is well-established in adult cohorts. This includes adjustments based on self-limited, large amplitude subject head motion, as well as factitious rhythmic motion induced by respiration. In adults, such respiration artifact can be effectively removed by applying a notch filter to the motion trace, resulting in higher amounts of data retained after frame censoring (e.g., "scrubbing") and more reliable correlation values. Due to the unique physiological and behavioral characteristics of infants and toddlers, rs-fMRI processing pipelines, including methods to identify and remove colored noise due to subject motion, must be appropriately modified to accurately reflect true neuronal signal. These younger cohorts are characterized by higher respiration rates and lower-amplitude head movements than adults; thus, the presence and significance of comparable respiratory artifact and the subsequent necessity of applying similar techniques remain unknown. Herein, we identify and characterize the consistent presence of respiratory artifact in rs-fMRI data collected during natural sleep in infants and toddlers across two independent cohorts (aged 8-24 months) analyzed using different pipelines. We further demonstrate how removing this artifact using an age-specific notch filter allows for both improved data quality and data retention in measured results. Importantly, this work reveals the critical need to identify and address respiratory-driven head motion in fMRI data acquired in young populations through the use of age-specific motion filters as a mechanism to optimize the accuracy of measured results in this population.

SUBMITTER: Kaplan S

PROVIDER: S-EPMC8803544 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Publications

Filtering respiratory motion artifact from resting state fMRI data in infant and toddler populations.

Kaplan Sydney S Meyer Dominique D Miranda-Dominguez Oscar O Perrone Anders A Earl Eric E Alexopoulos Dimitrios D Barch Deanna M DM Day Trevor K M TKM Dust Joseph J Eggebrecht Adam T AT Feczko Eric E Kardan Omid O Kenley Jeanette K JK Rogers Cynthia E CE Wheelock Muriah D MD Yacoub Essa E Rosenberg Monica M Elison Jed T JT Fair Damien A DA Smyser Christopher D CD

NeuroImage 20211220

The importance of motion correction when processing resting state functional magnetic resonance imaging (rs-fMRI) data is well-established in adult cohorts. This includes adjustments based on self-limited, large amplitude subject head motion, as well as factitious rhythmic motion induced by respiration. In adults, such respiration artifact can be effectively removed by applying a notch filter to the motion trace, resulting in higher amounts of data retained after frame censoring (e.g., "scrubbin ...[more]

PMID: 34942363

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Project description:The quality of functional MRI (fMRI) data is affected by head motion. It has been shown that fMRI data quality can be improved by prospectively updating the gradients and radio-frequency pulses in response to head motion during image acquisition by using an MR-compatible optical tracking system (prospective motion correction, or PMC). Recent studies showed that PMC improves the temporal Signal to Noise Ratio (tSNR) of resting state fMRI data (rs-fMRI) acquired from subjects not moving intentionally. Besides that, the time courses of Independent Components (ICs), resulting from Independent Component Analysis (ICA), were found to present significant temporal correlation with the motion parameters recorded by the camera. However, the benefits of applying PMC for improving the quality of rs-fMRI acquired under large head movements and its effects on resting state networks (RSN) and connectivity matrices are still unknown. In this study, subjects were instructed to cross their legs at will while rs-fMRI data with and without PMC were acquired, which generated head motion velocities ranging from 4 to 30 mm/s. We also acquired fMRI data without intentional motion. Independent component analysis of rs-fMRI was performed to evaluate IC maps and time courses of RSNs. We also calculated the temporal correlation among different brain regions and generated connectivity matrices for the different motion and PMC conditions. In our results we verified that the crossing leg movements reduced the tSNR of sessions without and with PMC by 45 and 20%, respectively, when compared to sessions without intentional movements. We have verified an interaction between head motion speed and PMC status, showing stronger attenuation of tSNR for acquisitions without PMC than for those with PMC. Additionally, the spatial definition of major RSNs, such as default mode, visual, left and right central executive networks, was improved when PMC was enabled. Furthermore, motion altered IC-time courses by decreasing power at low frequencies and increasing power at higher frequencies (typically associated with artefacts). PMC partially reversed these alterations of the power spectra. Finally, we showed that PMC provides temporal correlation matrices for data acquired under motion conditions more comparable to those obtained by fMRI sessions where subjects were instructed not to move.

Dataset Information

Filtering respiratory motion artifact from resting state fMRI data in infant and toddler populations.

Publications

Filtering respiratory motion artifact from resting state fMRI data in infant and toddler populations.

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