Ontology highlight
ABSTRACT:
SUBMITTER: Valdivia AO
PROVIDER: S-EPMC8805197 | biostudies-literature | 2022 Jan-Feb
REPOSITORIES: biostudies-literature
Valdivia Anddre Osmar AO Bhattacharya Sanjoy K SK
eNeuro 20220126 1
Protein hyperdeimination and deficiency of lyso-phospholipids (LPC 18:1) has been associated with the pathology of demyelinating disease in both humans and mice. We uncovered interesting biology of LPC 18:1, in which LPC 18:1 induced optic nerve function restoration through oligodendrocyte maturation and remyelination in mouse model systems. Our <i>in vitro</i> studies show LPC 18:1 protection against neuron-ectopic hyperdeimination and stimulation of oligodendrocyte maturation, while <i>in vivo ...[more]