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Does blood of healthy subjects contain bacterial ribosomal DNA?


ABSTRACT: Real-time PCR methods with primers and a probe targeting conserved regions of the bacterial 16S ribosomal DNA (rDNA) revealed a larger amount of rDNA in blood specimens from healthy individuals than in matched reagent controls. However, the origins and identities of these blood-associated bacterial rDNA sequences remain obscure.

SUBMITTER: Nikkari S 

PROVIDER: S-EPMC88056 | biostudies-literature | 2001 May

REPOSITORIES: biostudies-literature

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Does blood of healthy subjects contain bacterial ribosomal DNA?

Nikkari S S   McLaughlin I J IJ   Bi W W   Dodge D E DE   Relman D A DA  

Journal of clinical microbiology 20010501 5


Real-time PCR methods with primers and a probe targeting conserved regions of the bacterial 16S ribosomal DNA (rDNA) revealed a larger amount of rDNA in blood specimens from healthy individuals than in matched reagent controls. However, the origins and identities of these blood-associated bacterial rDNA sequences remain obscure. ...[more]

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