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Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study.

ABSTRACT: The clinicopathological value of microRNA-141-3p (miR-141-3p) and its prospective target genes in endometrial carcinoma (EC) remains unclear. The present study determined the expression level of miR-141-3p in EC via quantitative real-time PCR (RT-qPCR). RT-qPCR showed a markedly higher expression level of miR-141-3p in EC tissues than in non-EC endometrium tissues (P < 0.0001). The microarray and miRNA-seq data revealed upregulation of miR-141-3p. Integrated analysis based on 675 cases of EC and 63 controls gave a standardized mean difference of 1.737, confirmed the upregulation of miR-141-3p. The Kaplan-Meier survival curve showed that a higher expression of miR-141-3p positively corelated with a poorer prognosis. Combining the predicted targets and downregulated genes in EC, we obtained 271 target genes for miR-141-3p in EC. Two potential targets, PPP1R12A and PPP1R12B, were downregulated at both the mRNA and protein levels. This study indicates that the overexpression of miR-141-3p may play an important part in the carcinogenesis of EC. The overexpression of miR-141-3p may be a risk factor for the prognosis of patients with EC.

SUBMITTER: Yang LJ

PROVIDER: S-EPMC8806562 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study.

Yang Lin-Jie LJ Gao Li L Guo Yi-Nan YN Liang Zi-Qian ZQ Li Dong-Ming DM Tang Yu-Lu YL Liu Yi-Hong YH Gao Wan-Jing WJ Zeng Jing-Jing JJ Shi Lin L Wei Kang-Lai KL Chen Gang G

Bioengineered 20211201 1

The clinicopathological value of microRNA-141-3p (miR-141-3p) and its prospective target genes in endometrial carcinoma (EC) remains unclear. The present study determined the expression level of miR-141-3p in EC via quantitative real-time PCR (RT-qPCR). RT-qPCR showed a markedly higher expression level of miR-141-3p in EC tissues than in non-EC endometrium tissues (<i>P</i> < 0.0001). The microarray and miRNA-seq data revealed upregulation of miR-141-3p. Integrated analysis based on 675 cases of ...[more]

PMID: 34180758

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Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study.

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Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study.

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