Ontology highlight
ABSTRACT:
SUBMITTER: Napoli M
PROVIDER: S-EPMC8807845 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Napoli Marco M Wu Sarah J SJ Gore Bethanie L BL Abbas Hussein A HA Lee Kyubum K Checker Rahul R Dhar Shilpa S Rajapakshe Kimal K Tan Aik Choon AC Lee Min Gyu MG Coarfa Cristian C Flores Elsa R ER
Nature communications 20220201 1
Distinct lung stem cells give rise to lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC). ΔNp63, the p53 family member and p63 isoform, guides the maturation of these stem cells through the regulation of their self-renewal and terminal differentiation; however, the underlying mechanistic role regulated by ∆Np63 in lung cancer development has remained elusive. By utilizing a ΔNp63-specific conditional knockout mouse model and xenograft models of LUAD and LUSC, we found that ∆Np63 promo ...[more]