Dataset Information

Testing influences of APOE and BDNF genes and heart failure on cognitive function.

ABSTRACT:

Background

Apolipoprotein E (APOE) ε2, ε4 and brain-derived neurotrophic factor (BDNF) Val66Met alleles have been associated with cognition. Associations of these alleles with cognition in heart failure (HF) and influences of HF across the cognitive spectrum (i.e., cognitively normal to Alzheimer's dementia [AD]) remain unexplored.

Objectives

To investigate influences of APOE ε2, ε4, BDNF Met and HF on cognition among participants across the cognitive spectrum.

Methods

Genetic association study using national databases (N = 7,166).

Results

APOE ε2 frequencies were similar across the cognitive spectrum among participants with HF. APOE ε4 frequency was lower among participants with HF and AD than non-HF participants with AD. BDNF Met frequencies did not differ across the spectrum. HF was associated with worse attention and language. In the HF subsample, ε4 was associated with worse memory.

Conclusion

Associations between APOE and cognition may differ in HF but need to be tested in a larger sample.

SUBMITTER: Jung M

PROVIDER: S-EPMC8809626 | biostudies-literature | 2021 Jan - Feb

REPOSITORIES: biostudies-literature

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Publications

Testing influences of APOE and BDNF genes and heart failure on cognitive function.

Jung Miyeon M Apostolova Liana G LG Gao Sujuan S Burney Heather N HN Lai Dongbing D Foroud Tatiana T Saykin Andrew J AJ Pressler Susan J SJ

Heart & lung : the journal of critical care 20200720 1

<h4>Background</h4>Apolipoprotein E (APOE) ε2, ε4 and brain-derived neurotrophic factor (BDNF) Val66Met alleles have been associated with cognition. Associations of these alleles with cognition in heart failure (HF) and influences of HF across the cognitive spectrum (i.e., cognitively normal to Alzheimer's dementia [AD]) remain unexplored.<h4>Objectives</h4>To investigate influences of APOE ε2, ε4, BDNF Met and HF on cognition among participants across the cognitive spectrum.<h4>Methods</h4>Gene ...[more]

PMID: 32703621

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Project description:Patients with heart failure (HF) have high rates of cognitive impairment and depressive symptoms. Depressive symptoms have been associated with greater cognitive impairments in HF; however, it is not known whether particular clusters of depressive symptoms are more detrimental to cognition than others.The aim of this study was to identify whether somatic and/or nonsomatic depressive symptom clusters were associated with cognitive function in persons with HF.Participants were 326 HF patients (40.5% women, 26.7% non-white race-ethnicity, aged 68.6 ± 9.7 years). Depressive symptoms were measured using a depression questionnaire commonly used in medical populations: the Patient Health Questionnaire-9. Somatic and nonsomatic subscale scores were created using previous factor analytic results. A neuropsychological battery tested attention, executive function, and memory. Composites were created using averages of age-adjusted scaled scores. Regressions adjusting for demographic and clinical factors were conducted.Regressions revealed that Patient Health Questionnaire-9 total was associated with attention (? = -.14, P = .008) and executive function (? = -.17, P = .001). When analyzed separately, the nonsomatic subscale, but not the somatic symptoms subscale (P values ? .092), was associated with attention scores (? = -.15, P = .004) and memory (? = -.11, P = .044). Both nonsomatic (? = -.18, P < .001) and somatic (? = -.11, P = .048) symptoms were related to executive function. When included together, only the nonsomatic symptom cluster was associated with attention (? = -.15, P = .020) and executive function (? = -.19, P = .003).Greater overall depressive symptom severity was associated with poorer performance on multiple cognitive domains, an effect driven primarily by the nonsomatic symptoms of depression.These findings suggest that screening explicitly for nonsomatic depressive symptoms may be warranted and that the mechanisms underlying the depression-cognitive function relationship in HF are not solely related to sleep or appetite disturbance. Thus, interventions that target patients' somatic symptoms only (eg, poor appetite or fatigue) may not yield maximum cognitive benefit compared with a comprehensive treatment that targets depressed mood, anhedonia, and other nonsomatic symptoms.

Dataset Information

Testing influences of APOE and BDNF genes and heart failure on cognitive function.

Background

Objectives

Methods

Results

Conclusion

Publications

Testing influences of APOE and BDNF genes and heart failure on cognitive function.

Similar Datasets

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