Ontology highlight
ABSTRACT:
SUBMITTER: Balamurugan K
PROVIDER: S-EPMC8810408 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Balamurugan Keerthana K Medishetti Raghavender R Kotha Jyothi J Behera Parameshwar P Chandra Kanika K Mavuduru Vijay Aditya VA Joshi Manjunath B MB Samineni Ramesh R Katika Madhumohan R MR Ball Writoban Basu WB Thondamal Manjunatha M Challa Anil A Chatti Kiranam K Parsa Kishore V L KVL
iScience 20220112 2
Infiltration of arterial intima by foamy macrophages is a hallmark of early atherosclerotic lesions. Here, we investigated the potential role of Ser/Thr phosphatase PHLPP1 in foam cell development. PHLPP1 levels were elevated in OxLDL-exposed macrophages and high-fat diet (HFD)-fed zebrafish larvae. Using overexpression and knockdown approaches, we show that PHLPP1 promotes the accumulation of neutral lipids, and augments cellular total cholesterol and free fatty acid (FFA) levels. RNA-Seq analy ...[more]