Dataset Information

Urinary Cadmium and Incident Heart Failure: A Case-Cohort Analysis Among Never-Smokers in Denmark.

ABSTRACT:

Background

Epidemiologic studies suggest cadmium exposure is associated with cardiovascular disease risk, including heart failure. However, prior findings may be influenced by tobacco smoking, a dominant source of cadmium exposure and risk factor for heart failure. The present study leverages up to 20 years of follow-up in the Danish Diet, Cancer and Health cohort to examine the relationship between urinary cadmium and incident heart failure among people who never smoked.

Methods

Between 1993 and 1997, 19,394 never-smoking participants (ages 50-64 years) enrolled and provided a urine sample. From this sample, we randomly selected a subcohort of 600 men and 600 women and identified 958 incident heart failure cases occurring between baseline and 2015. Using a case-cohort approach, we estimated adjusted hazard ratios (aHR) for heart failure in Cox proportional hazards models with age as the time scale.

Results

Participants had relatively low concentrations of urinary cadmium, as expected for never smokers (median = 0.20; 25th, 75th = 0.13, 0.32 μg cadmium/g creatinine). In adjusted models, we found that higher urinary cadmium was associated with a higher rate of incident heart failure overall (aHR = 1.1 per interquartile range difference [95% CI = 1.0, 1.2). In sex-stratified analyses, the association seemed restricted to men (aHR = 1.5 [95% CI = 1.2, 1.9]).

Conclusions

In this cohort of people who never smoked tobacco, environmental cadmium was positively associated with incident heart failure, especially among men.

SUBMITTER: Sears CG

PROVIDER: S-EPMC8810592 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

Urinary Cadmium and Incident Heart Failure: A Case-Cohort Analysis Among Never-Smokers in Denmark.

Sears Clara G CG Eliot Melissa M Raaschou-Nielsen Ole O Poulsen Aslak Harbo AH Harrington James M JM Howe Chanelle J CJ James Katherine A KA Roswall Nina N Overvad Kim K Tjønneland Anne A Meliker Jaymie J Wellenius Gregory A GA

Epidemiology (Cambridge, Mass.) 20220301 2

<h4>Background</h4>Epidemiologic studies suggest cadmium exposure is associated with cardiovascular disease risk, including heart failure. However, prior findings may be influenced by tobacco smoking, a dominant source of cadmium exposure and risk factor for heart failure. The present study leverages up to 20 years of follow-up in the Danish Diet, Cancer and Health cohort to examine the relationship between urinary cadmium and incident heart failure among people who never smoked.<h4>Methods</h4> ...[more]

PMID: 34860726

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Dataset Information

Urinary Cadmium and Incident Heart Failure: A Case-Cohort Analysis Among Never-Smokers in Denmark.

Background

Methods

Results

Conclusions

Publications

Urinary Cadmium and Incident Heart Failure: A Case-Cohort Analysis Among Never-Smokers in Denmark.

Similar Datasets

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