Ontology highlight
ABSTRACT:
SUBMITTER: Fleming AM
PROVIDER: S-EPMC8810719 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Fleming Aaron M AM Chabot Michael B MB Nguyen Ngoc L B NLB Burrows Cynthia J CJ
Angewandte Chemie (International ed. in English) 20211229 7
Nucleic acids are chemically modified to fine-tune their properties for biological function. Chemical tools for selective tagging of base modifications enables new approaches; the photosensitizers riboflavin and anthraquinone were previously proposed to oxidize N<sup>6</sup> -methyladenine (m<sup>6</sup> A) or 5-methylcytosine (5mdC) selectively. Herein, riboflavin, anthraquinone, or Rose Bengal were allowed to react with the canonical nucleosides dA, dC, dG, and dT, and the modified bases 5mdC, ...[more]