Ontology highlight
ABSTRACT:
SUBMITTER: Parichha A
PROVIDER: S-EPMC8810795 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Parichha Arpan A Suresh Varun V Chatterjee Mallika M Kshirsagar Aditya A Ben-Reuven Lihi L Olender Tsviya T Taketo M Mark MM Radosevic Velena V Bobic-Rasonja Mihaela M Trnski Sara S Holtzman Michael J MJ Jovanov-Milosevic Nataša N Reiner Orly O Tole Shubha S
Nature communications 20220202 1
The choroid plexus secretes cerebrospinal fluid and is critical for the development and function of the brain. In the telencephalon, the choroid plexus epithelium arises from the Wnt- expressing cortical hem. Canonical Wnt signaling pathway molecules such as nuclear β-CATENIN are expressed in the mouse and human embryonic choroid plexus epithelium indicating that this pathway is active. Point mutations in human β-CATENIN are known to result in the constitutive activation of canonical Wnt signali ...[more]