Ontology highlight
ABSTRACT:
SUBMITTER: Guan Q
PROVIDER: S-EPMC8812173 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Guan Qian Q Lin Huiran H Miao Lei L Guo Huiqin H Chen Yongping Y Zhuo Zhenjian Z He Jing J
Journal of hematology & oncology 20220203 1
RNA modification plays a crucial role in many biological functions, and its abnormal regulation is associated with the progression of cancer. Among them, N<sup>6</sup>-methyladenine (m<sup>6</sup>A) is the most abundant RNA modification. Methyltransferase-like 14 (METTL14) is the central component of the m<sup>6</sup>A methylated transferase complex, which is involved in the dynamic reversible process of m<sup>6</sup>A modification. METTL14 acts as both an oncogene and tumor suppressor gene to r ...[more]