Ontology highlight
ABSTRACT:
SUBMITTER: Border R
PROVIDER: S-EPMC8814020 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Border Richard R O'Rourke Sean S de Candia Teresa T Goddard Michael E ME Visscher Peter M PM Yengo Loic L Jones Matt M Keller Matthew C MC
Nature communications 20220203 1
Many traits are subject to assortative mating, with recent molecular genetic findings confirming longstanding theoretical predictions that assortative mating induces long range dependence across causal variants. However, all marker-based heritability estimators implicitly assume mating is random. We provide mathematical and simulation-based evidence demonstrating that both method-of-moments and likelihood-based estimators are biased in the presence of assortative mating and derive corrected heri ...[more]