α9-Containing Nicotinic Receptors in Cancer.
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ABSTRACT:
SUBMITTER: Pucci S
PROVIDER: S-EPMC8814915 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
α9-Containing Nicotinic Receptors in Cancer.
Pucci Susanna S Zoli Michele M Clementi Francesco F Gotti Cecilia C
Frontiers in cellular neuroscience 20220121
Neuronal nicotinic acetylcholine receptors containing the α9 or the α9 and α10 subunits are expressed in various extra-neuronal tissues. Moreover, most cancer cells and tissues highly express α9-containing receptors, and a number of studies have shown that they are powerful regulators of responses that stimulate cancer processes such as proliferation, inhibition of apoptosis, and metastasis. It has also emerged that their modulation is a promising target for drug development. The aim of this rev ...[more]
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