Ontology highlight
ABSTRACT:
SUBMITTER: Malyavko AN
PROVIDER: S-EPMC8820739 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Malyavko Alexander N AN Petrova Olga A OA Zvereva Maria I MI Polshakov Vladimir I VI Dontsova Olga A OA
eLife 20220207
Rif1 is a large multifaceted protein involved in various processes of DNA metabolism - from telomere length regulation and replication to double-strand break repair. The mechanistic details of its action, however, are often poorly understood. Here, we report functional characterization of the Rif1 homologue from methylotrophic thermotolerant budding yeast <i>Hansenula polymorpha</i> DL-1. We show that, similar to other yeast species, <i>H. polymorpha</i> Rif1 suppresses telomerase-dependent telo ...[more]