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Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents.

ABSTRACT: A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds showed promising anticancer activities.

SUBMITTER: Alshabanah LA

PROVIDER: S-EPMC8822056 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Three-Component Synthesis of Some New Coumarin Derivatives as Anticancer Agents.

Alshabanah Latifah A LA Al-Mutabagani Laila A LA Gomha Sobhi M SM Ahmed Hoda A HA

Frontiers in chemistry 20220125

A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted poly(vinylpyridine) as an eco-friendly catalyst. The process is a simple, facile, efficient procedure for the preparation of compounds displaying a thiazole ring linked to coumarin moiety. Moreover, all the products were evaluated for their anticancer activities against HEPG2-1. The results revealed that three new compounds ...[more]

PMID: 35145952

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