Ontology highlight
ABSTRACT:
SUBMITTER: Lex RK
PROVIDER: S-EPMC8831537 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Lex Rachel K RK Zhou Weiqiang W Ji Zhicheng Z Falkenstein Kristin N KN Schuler Kaleigh E KE Windsor Kathryn E KE Kim Joseph D JD Ji Hongkai H Vokes Steven A SA
Nature communications 20220210 1
The Hedgehog (HH) pathway regulates a spectrum of developmental processes through the transcriptional mediation of GLI proteins. GLI repressors control tissue patterning by preventing sub-threshold activation of HH target genes, presumably even before HH induction, while lack of GLI repression activates most targets. Despite GLI repression being central to HH regulation, it is unknown when it first becomes established in HH-responsive tissues. Here, we investigate whether GLI3 prevents precociou ...[more]