Phylogenetic origin of hepatitis B virus strains with precore C-1858 variant.
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ABSTRACT:
SUBMITTER: Alestig E
PROVIDER: S-EPMC88319 | biostudies-literature | 2001 Sep
REPOSITORIES: biostudies-literature
Publications
Phylogenetic origin of hepatitis B virus strains with precore C-1858 variant.
Alestig E E Hannoun C C Horal P P Lindh M M
Journal of clinical microbiology 20010901 9
Mutations that prevent the expression of the hepatitis B e antigen frequently emerge in the immunoreactive phase of infection. The predominant mutation, the precore G-->A-1896 mutation, is restricted by the variability at position 1858 and is rare in strains with cytosine at nucleotide 1858. The C-1858 variant is characteristic of genotype A. It also occurs in genotypes C and F, but not in B, D, or E, explaining the geographical variation in the prevalence of precore mutants. C-1858 strains have ...[more]
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