Ontology highlight
ABSTRACT:
SUBMITTER: Evers SS
PROVIDER: S-EPMC8832374 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Evers Simon S SS Shao Yikai Y Ramakrishnan Sadeesh K SK Shin Jae Hoon JH Bozadjieva-Kramer Nadejda N Irmler Martin M Stemmer Kerstin K Sandoval Darleen A DA Shah Yatrik M YM Seeley Randy J RJ
Cell reports 20220101 3
Gastric bypass and vertical sleeve gastrectomy (VSG) remain the most potent and durable treatments for obesity and type 2 diabetes but are also associated with iron deficiency. The transcription factor HIF2α, which regulates iron absorption in the duodenum, increases following these surgeries. Increasing iron levels by means of dietary supplementation or hepatic hepcidin knockdown does not undermine the effects of VSG, indicating that metabolic improvements following VSG are not secondary to low ...[more]