Ontology highlight
ABSTRACT:
SUBMITTER: Kang YJ
PROVIDER: S-EPMC8835956 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Kang Yong Jung YJ Jang Jung Yoon JY Kwon Young Hoon YH Lee Jun Ho JH Lee Sanggwon S Park Yujin Y Jung Young-Suk YS Im Eunok E Moon Hyung Ryong HR Chung Hae Young HY Kim Nam Deuk ND
International journal of molecular sciences 20220129 3
Sirtuins (SIRTs), which are nicotinamide adenine dinucleotide-dependent class III histone deacetylases, regulate cell division, survival, and senescence. Although sirtinol, a synthetic SIRT inhibitor, is known to exhibit antitumor effects, its mechanism of action is not well understood. Therefore, we aimed to assess the anticancer effects and underlying mechanism of MHY2245, a derivative of sirtinol, in HCT116 human colorectal cancer cells in vitro. Treatment with MHY2245 decreased SIRT1 activit ...[more]