Clinical characteristics of SARS-CoV-2 fully-vaccinated patients dying with COVID-19 in Italy.
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ABSTRACT:
SUBMITTER: Palmieri L
PROVIDER: S-EPMC8843808 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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Clinical characteristics of SARS-CoV-2 fully-vaccinated patients dying with COVID-19 in Italy.
Palmieri Luigi L Floridia Marco M Giuliano Marina M Tiple Dorina D Lo Noce Cinzia C Meli Paola P Onder Graziano G
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20220215 6
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Project description:BackgroundTo evaluate the differences in the clinical characteristics and severity of lung impairment, assessed by quantitative lung CT scan, between vaccinated and non-vaccinated hospitalized patients with COVID-19; and to identify the variables with best prognostic prediction according to SARS-CoV-2 vaccination status. We recorded clinical, laboratory and quantitative lung CT scan data in 684 consecutive patients [580 (84.8%) vaccinated, and 104 (15.2%) non-vaccinated], admitted between January and December 2021.ResultsVaccinated patients were significantly older 78 [69-84] vs 67 [53-79] years and with more comorbidities. Vaccinated and non-vaccinated patients had similar PaO2/FiO2 (300 [252-342] vs 307 [247-357] mmHg; respiratory rate 22 [8-26] vs 19 [18-26] bpm); total lung weight (918 [780-1069] vs 954 [802-1149] g), lung gas volume (2579 [1801-3628] vs 2370 [1675-3289] mL) and non-aerated tissue fraction (10 [7.3-16.0] vs 8.5 [6.0-14.1] %). The overall crude hospital mortality was similar between the vaccinated and non-vaccinated group (23.1% vs 21.2%). However, Cox regression analysis, adjusted for age, ethnicity, age unadjusted Charlson Comorbidity Index and calendar month of admission, showed a 40% reduction in hospital mortality in the vaccinated patients (HRadj = 0.60, 95%CI 0.38-0.95).ConclusionsHospitalized vaccinated patients with COVID-19, although older and with more comorbidities, presented a similar impairment in gas exchange and lung CT scan compared to non-vaccinated patients, but were at a lower risk of mortality.
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