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Cu(I)-Catalyzed Alkynylation of Quinolones.

ABSTRACT: Herein we report the first alkynylation of quinolones with terminal alkynes under mild reaction conditions. The reaction is catalyzed by Cu(I) salts in the presence of a Lewis acid, which is essential for the reactivity of the system. The enantioselective version of this transformation has also been explored, and the methodology has been applied in the synthesis of the enantioenriched tetrahydroquinoline alkaloid cuspareine.

SUBMITTER: Maestro A

PROVIDER: S-EPMC8845045 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Cu(I)-Catalyzed Alkynylation of Quinolones.

Maestro Aitor A Lemaire Sebastien S Harutyunyan Syuzanna R SR

Organic letters 20220131 5

Herein we report the first alkynylation of quinolones with terminal alkynes under mild reaction conditions. The reaction is catalyzed by Cu(I) salts in the presence of a Lewis acid, which is essential for the reactivity of the system. The enantioselective version of this transformation has also been explored, and the methodology has been applied in the synthesis of the enantioenriched tetrahydroquinoline alkaloid cuspareine. ...[more]

PMID: 35099185

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