Dataset Information

Dietary Factors and Gastric Intestinal Metaplasia Risk Among US Veterans.

ABSTRACT:

Background

Studies on diet and gastric intestinal metaplasia (GIM) risk are lacking in US populations.

Aim

To determine the associations of dietary factors and risk of GIM among a US population with typical American diet.

Methods

We analyzed data from a cross-sectional study of veterans attending primary care and endoscopy clinics at the Houston VA Medical Center. Patients completed a 110-item Block Food Frequency Questionnaire then underwent upper endoscopy with gastric mapping biopsies. We compared cases defined by GIM on ≥ 1 non-cardia gastric biopsy to controls without GIM. Associations of dietary factors and GIM were estimated using logistic regression models as odds ratios (OR) and 95% confidence intervals (CI).

Results

Among 423 GIM cases and 1796 controls, cases were older (62.1 vs. 59.9 years) and more likely to be male (97.2% vs. 90.8%) and non-White (58.6% vs. 39.0%). GIM cases had lower fat intake (percent kcal from fat tertile 1: 43.6% vs. 33.4%) and higher carbohydrate intake (percent kcal from carbohydrate T3: 41.8% vs. 33.3%) than controls. Adjusting for age, gender, race, smoking, and Helicobacter pylori, percent kcal from carbohydrates (T3 vs. T1: OR 1.35, 95% CI 1.08-1.67), fruit intake (T3 vs. T1: OR 1.28, 95% CI 1.02-1.61), and fiber intake (T3 vs. T1: OR 1.37, 95% CI 1.04-1.80) were associated with GIM. In subgroup analyses, these associations were primarily seen in non-White patients.

Conclusions

Few dietary factors, including high carbohydrate intake, are associated with increased risk of GIM in US populations, independent of H. pylori or smoking.

SUBMITTER: Tan MC

PROVIDER: S-EPMC8845052 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Publications

Dietary Factors and Gastric Intestinal Metaplasia Risk Among US Veterans.

Tan Mimi C MC Mallepally Niharika N Ho Quynh Q Liu Yan Y El-Serag Hashem B HB Thrift Aaron P AP

Digestive diseases and sciences 20200613 5

<h4>Background</h4>Studies on diet and gastric intestinal metaplasia (GIM) risk are lacking in US populations.<h4>Aim</h4>To determine the associations of dietary factors and risk of GIM among a US population with typical American diet.<h4>Methods</h4>We analyzed data from a cross-sectional study of veterans attending primary care and endoscopy clinics at the Houston VA Medical Center. Patients completed a 110-item Block Food Frequency Questionnaire then underwent upper endoscopy with gastric ma ...[more]

PMID: 32535778

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Dataset Information

Dietary Factors and Gastric Intestinal Metaplasia Risk Among US Veterans.

Background

Aim

Methods

Results

Conclusions

Publications

Dietary Factors and Gastric Intestinal Metaplasia Risk Among US Veterans.

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