Inhaled pulmonary vasodilators are not associated with improved gas exchange in mechanically ventilated patients with COVID-19: A retrospective cohort study.

ABSTRACT:

Purpose

Measure the effect of inhaled pulmonary vasodilators on gas exchange in mechanically ventilated patients with COVID-19.

Methods

A retrospective observational cohort study at three New York University Hospitals was performed including eighty-four mechanically ventilated SARS Cov-2 nasopharyngeal PCR positive patients, sixty nine treated with inhaled nitric oxide (iNO) and fifteen with inhaled epoprostenol (iEPO). The primary outcomes were change in P_AO₂:F_IO₂ ratio, oxygenation Index (OI), and ventilatory ratio (VR) after initiation of inhaled pulmonary vasodilators.

Results

There was no significant change in P_AO₂:F_IO₂ratio after initiation of iNO (mean - 4.1, 95% CI -17.3-9.

SUBMITTER: Lubinsky AS 

PROVIDER: S-EPMC8847100 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature