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Erythrocytes Induce Vascular Dysfunction in COVID-19.

ABSTRACT: Current knowledge regarding mechanisms underlying cardiovascular complications in patients with COVID-19 is limited and urgently needed. We shed light on a previously unrecognized mechanism and unravel a key role of red blood cells, driving vascular dysfunction in patients with COVID-19 infection. We establish the presence of profound and persistent endothelial dysfunction in vivo in patients with COVID-19. Mechanistically, we show that targeting reactive oxygen species or arginase 1 improves vascular dysfunction mediated by red blood cells. These translational observations hold promise that restoring the redox balance in red blood cells might alleviate the clinical complications of COVID-19-associated vascular dysfunction.

SUBMITTER: Mahdi A

PROVIDER: S-EPMC8849181 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Erythrocytes Induce Vascular Dysfunction in COVID-19.

Mahdi Ali A Collado Aida A Tengbom John J Jiao Tong T Wodaje Tigist T Johansson Niclas N Farnebo Filip F Färnert Anna A Yang Jiangning J Lundberg Jon O JO Zhou Zhichao Z Pernow John J

JACC. Basic to translational science 20220216 3

Current knowledge regarding mechanisms underlying cardiovascular complications in patients with COVID-19 is limited and urgently needed. We shed light on a previously unrecognized mechanism and unravel a key role of red blood cells, driving vascular dysfunction in patients with COVID-19 infection. We establish the presence of profound and persistent endothelial dysfunction <i>in vivo</i> in patients with COVID-19. Mechanistically, we show that targeting reactive oxygen species or arginase 1 impr ...[more]

PMID: 35194565

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