Low Bone Mineral Density in Hemophiliacs.
Ontology highlight
ABSTRACT: Objective
To review the current knowledge on bone health in patients with hemophilia A and the underlying pathogenetic mechanisms.Data sources
Original research articles, meta-analyses, and scientific reviews.Data synthesis
Already in childhood, patients with hemophilia A are prone to low bone mineral density, leading to osteopenia and/or osteoporosis. Initially associated with the life style of hemophilia, today we are faced with accumulating evidence that coagulation factor VIII is involved directly or indirectly in bone physiology.Conclusion
Understanding the role of factor VIII and the mechanisms of decreased bone mineral density in hemophilia A is critically important, especially as non-factor replacement therapies are available, and treatment decisions potentially impact bone health.
SUBMITTER: Gebetsberger J
PROVIDER: S-EPMC8849249 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Low Bone Mineral Density in Hemophiliacs.
Gebetsberger Jennifer J Schirmer Michael M Wurzer Walter J WJ Streif Werner W
Frontiers in medicine 20220202
<h4>Objective</h4>To review the current knowledge on bone health in patients with hemophilia A and the underlying pathogenetic mechanisms.<h4>Data sources</h4>Original research articles, meta-analyses, and scientific reviews.<h4>Data synthesis</h4>Already in childhood, patients with hemophilia A are prone to low bone mineral density, leading to osteopenia and/or osteoporosis. Initially associated with the life style of hemophilia, today we are faced with accumulating evidence that coagulation fa ...[more]
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