Ontology highlight
ABSTRACT:
SUBMITTER: Pellini B
PROVIDER: S-EPMC8853615 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Pellini Bruna B Chaudhuri Aadel A AA
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20220105 6
Circulating tumor DNA (ctDNA) minimal residual disease (MRD) is a powerful biomarker with the potential to improve survival outcomes for non-small-cell lung cancer (NSCLC). Multiple groups have shown the ability to detect MRD following curative-intent NSCLC treatment using next-generation sequencing-based assays of plasma cell-free DNA. These studies have been modest in size, largely retrospective, and without thorough prospective clinical validation. Still, when restricting measurement to the f ...[more]