Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass.
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ABSTRACT:
SUBMITTER: Gharibi H
PROVIDER: S-EPMC8855419 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Abnormal (Hydroxy)proline Deuterium Content Redefines Hydrogen Chemical Mass.
Gharibi Hassan H Chernobrovkin Alexey L AL Eriksson Gunilla G Saei Amir Ata AA Timmons Zena Z Kitchener Andrew C AC Kalthoff Daniela C DC Lidén Kerstin K Makarov Alexander A AA Zubarev Roman A RA
Journal of the American Chemical Society 20220202 6
Analyzing the δ<sup>2</sup>H values in individual amino acids of proteins extracted from vertebrates, we unexpectedly found in some samples, notably bone collagen from seals, more than twice as much deuterium in proline and hydroxyproline residues than in seawater. This corresponds to at least 4 times higher δ<sup>2</sup>H than in any previously reported biogenic sample. We ruled out diet as a plausible mechanism for such anomalous enrichment. This finding puts into question the old adage that " ...[more]
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