Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC8857079 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Wang Yue Y Zhang Menghan M Bi Ran R Su Yali Y Quan Fei F Lin Yanting Y Yue Chongxiu C Cui Xinmeng X Zhao Qixiang Q Liu Siliang S Yang Yong Y Zhang Dayong D Cao Qiuhua Q Gao Xinghua X
Redox biology 20220209
The term ferroptosis coined in 2012 causes acute kidney injury (AKI). However, its pathway mechanism in AKI is poorly understood. In this study, we conducted an RNA-sequence analysis of kidneys in AKI and normal mice to explore the pathway mechanism of ferroptosis. Consequently, differentially expressed genes highlighted Acyl-CoA synthetase long-chain family (ACSL4), a known promotor for ferroptosis. Besides, RT-PCR, Western blot, and immunohistochemical analyses confirmed its upregulation. HIF- ...[more]