Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline.
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ABSTRACT:
SUBMITTER: Cucos CA
PROVIDER: S-EPMC8857523 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Sulfiredoxin-1 blood mRNA expression levels negatively correlate with hippocampal atrophy and cognitive decline.
Cucos Catalina Anca CA Cracana Ioana I Dobre Maria M Popescu Bogdan Ovidiu BO Tudose Catalina C Spiru Luiza L Manda Gina G Niculescu Gabriela G Milanesi Elena E
F1000Research 20220128
<b>Introduction:</b> Cognitive decline, correlating with hippocampal atrophy, characterizes several neurodegenerative disorders having a background of low-level chronic inflammation and oxidative stress. <b>Methods:</b> In this cross-sectional study, we examined how cognitive decline and hippocampal subfields volume are associated with the expression of redox and inflammatory genes in peripheral blood. We analyzed 34 individuals with different cognitive scores according to Mini-Mental State Exam ...[more]
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Project description:Comparison of hippocampal gene expression between normal young animals and older animals with good spatial memory and older animals with poor spatial memory
2009-01-15 | GSE13799 | GEO
Project description:Recent microarray studies in the hippocampus of rodents or Alzheimerâs disease (AD) subjects have identified a substantial number of cellular pathways/processes correlated with aging and cognitive decline. However, the temporal relationships among these expression changes or with cognitive impairment have not been studied in depth. Here, using Affymetrix microarrays, immunohistochemistry and Morris water maze cognitive testing across 5 age groups of male F344 rats (n=9-15/group, one microarray per animal), we systematically analyzed the temporal sequence and cellular localization of aging changes in expression. These were correlated with performance scores on the hippocampus-dependent Morris Water Maze task. 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2009-01-25 | E-GEOD-9990 | biostudies-arrayexpress
Project description:IntroductionWe sought to determine whether survival motor neuron (SMN) protein blood levels correlate with denervation and SMN2 copies in spinal muscular atrophy (SMA).MethodsUsing a mixed-effect model, we tested associations between SMN levels, compound muscle action potential (CMAP), and SMN2 copies in a cohort of 74 patients with SMA. We analyzed a subset of 19 of these patients plus four additional patients who had been treated with received gene therapy to examine SMN trajectories early in life.ResultsPatients with SMA who had lower CMAP values had lower circulating SMN levels (P = .04). Survival motor neuron protein levels were different between patients with two and three SMN2 copies (P < .0001) and between symptomatic and presymptomatic patients (P < .0001), with the highest levels after birth and progressive decline over the first 3 years. Neither nusinersen nor gene therapy clearly altered SMN levels.DiscussionThese data provide evidence that whole blood SMN levels correlate with SMN2 copy number and severity of denervation.
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2014-09-23 | E-GEOD-61326 | biostudies-arrayexpress
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