Dataset Information
Zinc-metal-organic frameworks with tunable UV diffuse-reflectance as sunscreens.
Ontology highlight
ABSTRACT: Background
UV exposure continues to induce many health issues, though commercial sunscreens are available. Novel UV filters with high safety and efficacy are urgently needed. Metal-organic frameworks (MOFs) could be a suitable platform for UV filter development, due to their tunable optical, electrical, and photoelectric properties by precise controlled synthesis.Results
Herein, four zinc-based MOFs with various bandgap energies were chose to investigate their optical behaviors and evaluate their possibility as sunscreens. Zeolitic imidazolate framework-8 (ZIF-8) was found to possess the highest and widest UV reflectance, thereby protecting against sunburn and DNA damage on mouse skin and even achieving a comparable or higher anti-UV efficacy relative to the commercially available UV filters, TiO2 or ZnO, on pig skin, a model that correlates well with human skin. Also, ZIF-8 exerted appealing characteristics for topical skin use with low radical production, low skin penetration, low toxicity, high transparency, and high stability.Conclusion
These results confirmed ZIF-8 could potentially be a safe and effective sunscreen surrogate for human, and MOFs could be a novel source to develop more effective and safe UV filters.
SUBMITTER: Xiao J
PROVIDER: S-EPMC8858458 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
Publications
Zinc-metal-organic frameworks with tunable UV diffuse-reflectance as sunscreens.
Journal of nanobiotechnology 20220219 1
<h4>Background</h4>UV exposure continues to induce many health issues, though commercial sunscreens are available. Novel UV filters with high safety and efficacy are urgently needed. Metal-organic frameworks (MOFs) could be a suitable platform for UV filter development, due to their tunable optical, electrical, and photoelectric properties by precise controlled synthesis.<h4>Results</h4>Herein, four zinc-based MOFs with various bandgap energies were chose to investigate their optical behaviors a ...[more]