Unknown

Dataset Information

0

Impact of platelet transfusion on outcomes in trauma patients.


ABSTRACT:

Background

Trauma-induced coagulopathy includes thrombocytopenia and platelet dysfunction that impact patient outcome. Nevertheless, the role of platelet transfusion remains poorly defined. The aim of the study was 1/ to evaluate the impact of early platelet transfusion on 24-h all-cause mortality and 2/ to describe platelet count at admission (PCA) and its relationship with trauma severity and outcome.

Methods

Observational study carried out on a multicentre prospective trauma registry. All adult trauma patients directly admitted in participating trauma centres between May 2011 and June 2019 were included. Severe haemorrhage was defined as ≥ 4 red blood cell units within 6 h and/or death from exsanguination. The impact of PCA and early platelet transfusion (i.e. within the first 6 h) on 24-h all-cause mortality was assessed using uni- and multivariate logistic regression.

Results

Among the 19,596 included patients, PCA (229 G/L [189,271]) was associated with coagulopathy, traumatic burden, shock and bleeding severity. In a logistic regression model, 24-h all-cause mortality increased by 37% for every 50 G/L decrease in platelet count (OR 0.63 95% CI 0.57-0.70; p < 0.001). Regarding patients with severe hemorrhage, platelets were transfused early for 36% of patients. Early platelet transfusion was associated with a decrease in 24-h all-cause mortality (versus no or late platelets): OR 0.52 (95% CI 0.34-0.79; p < 0.05).

Conclusions

PCA, although mainly in normal range, was associated with trauma severity and coagulopathy and was predictive of bleeding intensity and outcome. Early platelet transfusion within 6 h was associated with a decrease in mortality in patients with severe hemorrhage. Future studies are needed to determine which doses of platelet transfusion will improve outcomes after major trauma.

SUBMITTER: Hamada SR 

PROVIDER: S-EPMC8862339 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Impact of platelet transfusion on outcomes in trauma patients.

Hamada S R SR   Garrigue D D   Nougue H H   Meyer A A   Boutonnet M M   Meaudre E E   Culver A A   Gaertner E E   Audibert G G   Vigué B B   Duranteau J J   Godier A A  

Critical care (London, England) 20220221 1


<h4>Background</h4>Trauma-induced coagulopathy includes thrombocytopenia and platelet dysfunction that impact patient outcome. Nevertheless, the role of platelet transfusion remains poorly defined. The aim of the study was 1/ to evaluate the impact of early platelet transfusion on 24-h all-cause mortality and 2/ to describe platelet count at admission (PCA) and its relationship with trauma severity and outcome.<h4>Methods</h4>Observational study carried out on a multicentre prospective trauma re  ...[more]

Similar Datasets

| S-EPMC10485857 | biostudies-literature
| S-EPMC8906242 | biostudies-literature
| S-EPMC4409495 | biostudies-other
| S-EPMC5176217 | biostudies-literature
| S-EPMC3369689 | biostudies-literature
| S-EPMC7465283 | biostudies-literature
| S-EPMC11461267 | biostudies-literature
| S-EPMC4022636 | biostudies-literature
| S-EPMC11822007 | biostudies-literature
| S-EPMC6211165 | biostudies-other