Ontology highlight
ABSTRACT:
SUBMITTER: Liu M
PROVIDER: S-EPMC8862745 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Liu Miaomiao M Littler Dene R DR Rossjohn Jamie J Quinn Ronald J RJ
ACS omega 20220215 8
SARS-CoV-2 (COVID-19) has infected over 219 million people and caused the death of over 4.55 million worldwide. In a previous screen of a natural product library against purified SARS-CoV-2 Nsp9 using a native mass spectrometry-based approach, we identified an <i>ent-</i>kaurane natural product, oridonin (<b>1</b>), with micromolar affinities. In this work, we have found that the prodrug HAO472 (<b>2</b>) directly binds to Nsp9, establishing replacement of the labile ester with a bioisostere as ...[more]