Dataset Information

Outcomes in hospitalised patients with sepsis, severe sepsis or septic shock and reported penicillin allergy: a retrospective cohort study.

ABSTRACT:

Objective

To determine outcomes in hospitalised patients with sepsis and reported penicillin allergy (PcnA).

Design

Observational retrospective cohort study using data from electronic health records.

Setting

A large single health system with 11 hospitals of small, medium and large sizes including a 630-bed tertiary care teaching hospital.

Participants

Patients (n=5238) ≥18 years of age, hospitalised with sepsis, severe sepsis or septic shock between 1 January 2016 and 31 December 2018, received antibacterial agents, and had documented PcnA status. Patients <18 years of age at admission were excluded.

Outcome measures

Primary outcomes evaluated were inpatient mortality and 30-day mortality posthospital discharge. Secondary outcomes were hospital length of stay, 30-day readmissions, duration of antibiotic use, rate of Clostridium difficile infection and total cost of care.

Results

There was no difference in outcomes including inpatient or 30-day mortality, hospital length of stay, in-hospital antibiotic duration, C. difficile infection, total cost of care and 30-day readmission rate between patients labelled with a PcnA vs patients who did not report PcnA (non-PcnA).

Conclusion

In this retrospective single health system study, there was no difference in key outcomes including inpatient or 30-day mortality in patients admitted with sepsis and reported PcnA compared with patients who reported no PcnA.

SUBMITTER: Beddow D

PROVIDER: S-EPMC8867335 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Publications

Outcomes in hospitalised patients with sepsis, severe sepsis or septic shock and reported penicillin allergy: a retrospective cohort study.

Beddow David D Patel Love L Smith Claire S CS Kirven Justin J Schmidt Christine C Ruppman Daniel D Kethireddy Rajesh R Wankum Michael M Dawud Barite B St Hill Catherine A CA

BMJ open 20220223 2

<h4>Objective</h4>To determine outcomes in hospitalised patients with sepsis and reported penicillin allergy (PcnA).<h4>Design</h4>Observational retrospective cohort study using data from electronic health records.<h4>Setting</h4>A large single health system with 11 hospitals of small, medium and large sizes including a 630-bed tertiary care teaching hospital.<h4>Participants</h4>Patients (n=5238) ≥18 years of age, hospitalised with sepsis, severe sepsis or septic shock between 1 January 2016 an ...[more]

PMID: 35197334

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Dataset Information

Outcomes in hospitalised patients with sepsis, severe sepsis or septic shock and reported penicillin allergy: a retrospective cohort study.

Objective

Design

Setting

Participants

Outcome measures

Results

Conclusion

Publications

Outcomes in hospitalised patients with sepsis, severe sepsis or septic shock and reported penicillin allergy: a retrospective cohort study.

Similar Datasets

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